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[Pharmacokinetics of contraceptive steroids with reference to long-term administration].
- Source :
-
Zentralblatt fur Gynakologie [Zentralbl Gynakol] 1991; Vol. 113 (23), pp. 1298-303. - Publication Year :
- 1991
-
Abstract
- Pharmacokinetic investigations (c0h, c2h, c6h, c24h, AUC24) were carried out both in the first and last four days of a treatment cycle in patients of different ages, who used oral contraceptives at least for 12 months. 57 women took the preparation Trisiston (three-step-formulation with the components 0.03 mg ethinylestradiol (EE2) + 0.05 mg levonorgestrel (LNG), 0.04 mg EE2 + 0.075 mg LNG, 0.03 mg EE2 + 0.125 mg LNG), 23 subjects used Gravistat (0.05 mg EE2 + 0.125 mg LNG) and 17 patients were under Certostat, a preparation still in clinical evaluation (0.05 mg EE2 + 2.0 mg Dienogest (DNG)). The levels of EE2, LNG and DNG were measured by means of radioimmunoassays. Between the concentrations obtained after administration of a first and single tablet (earlier investigations) and those determined in long-time users during the first 4 days following the tablet-free interval no qualitative and quantitative differences were observed. Between the levels of EE2 and LNG determined in the first and last days of the treatment cycle, marked differences were found in patients under the formulations Trisiston and Gravistat, but not in those taking Certostat. It is concluded that a cyclic and reversible cumulating effect emerges under the influence of LNG-containing contraceptives, the mechanism of which cannot be explained solely by the increase of carrier protein capacity. It seems possibly due to an alteration of steroid metabolism resulting from the interaction between both components.
- Subjects :
- Adolescent
Adult
Ethinyl Estradiol-Norgestrel Combination
Female
Humans
Menstrual Cycle drug effects
Menstrual Cycle physiology
Middle Aged
Nandrolone administration & dosage
Nandrolone pharmacokinetics
Reference Values
Contraceptives, Oral, Hormonal administration & dosage
Contraceptives, Oral, Hormonal pharmacokinetics
Ethinyl Estradiol administration & dosage
Ethinyl Estradiol pharmacokinetics
Nandrolone analogs & derivatives
Norgestrel administration & dosage
Norgestrel pharmacokinetics
Subjects
Details
- Language :
- German
- ISSN :
- 0044-4197
- Volume :
- 113
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Zentralblatt fur Gynakologie
- Publication Type :
- Academic Journal
- Accession number :
- 1796663