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Bone marrow mononuclear stem cells transplanted in rat infarct myocardium improved the electrical conduction without evidence of proarrhythmic effects.
- Source :
-
Yonsei medical journal [Yonsei Med J] 2007 Oct 31; Vol. 48 (5), pp. 754-64. - Publication Year :
- 2007
-
Abstract
- Purpose: The arrhythmogenic effect of stem cells transplantation (SCT) in an infarct myocardium is still unknown. We investigated arrhythmogenicity of SCT in rat cryo-infarct model.<br />Materials and Methods: In rat cryo-infarct model, bone marrow mononuclear stem cells (MNSC, 1 x 10(7) cells) were transplanted into the infarct border zone (BZ) of the LV epicardium. We compared the optical mapping and inducibility of ventricular tachycardia/fibrillation (VT/VF) among normal (n=5), cryo-infarct (n=6), and SCT rats (n=6).<br />Results: The VT/VF inducibility was higher in the cryo- infarct (47.2%, p=0.001) and SCT groups (34.6%, p=0.01) than in the normal group (12.8%). The induced VT/VF episodes persisted for more than 2 minutes in 4.3%, 26.4% and 17.3% in the normal, cryo-infarct and SCT group, respectively. In the SCT group, the action potential duration at 70% was shorter at the SCT site than the BZ during SR (75.2 +/- 8.1 vs. 145.6 +/- 4.4 ms, p=0.001) and VT (78.2 +/- 13.0 vs. 125.7 +/- 21.0 ms, p= 0.001). Conduction block was observed at the SCT site and BZ during VT. However, no reentry or ectopic foci were observed around the SCT sites.<br />Conclusion: The electrical conduction was improved by SCT without evidence of augmentation of arrhythmia in the rat cryo-infarct model.
- Subjects :
- Action Potentials
Animals
Disease Models, Animal
Electric Conductivity
Heart Ventricles pathology
Heart Ventricles transplantation
In Vitro Techniques
Myocardial Infarction pathology
Rats
Rats, Sprague-Dawley
Arrhythmias, Cardiac etiology
Bone Marrow Transplantation adverse effects
Hematopoietic Stem Cell Transplantation adverse effects
Myocardial Infarction surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0513-5796
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Yonsei medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 17963331
- Full Text :
- https://doi.org/10.3349/ymj.2007.48.5.754