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Uterine development in Turner syndrome.
- Source :
-
The Journal of pediatrics [J Pediatr] 2007 Nov; Vol. 151 (5), pp. 528-31, 531.e1. Date of Electronic Publication: 2007 Sep 17. - Publication Year :
- 2007
-
Abstract
- Objective: To evaluate uterine development of women with Turner syndrome (TS) receiving conventional medical care.<br />Study Design: In a cross-sectional study we used ultrasonography for uterine evaluation in 86 women with TS 18 to 45 years of age participating in an intramural NIH study, and who had abnormal karyotypes in >70% of white blood cells. Outcomes were uterine dimensions and shape. Information on hormone treatment was obtained by personal interview.<br />Results: Twenty-five percent had a mature in size and shape uterus, and 31% had an immature uterus, with the remainder in a transitional category. Twenty percent of all participants were not taking hormone replacement therapy (HRT) in the preceding year. The majority on treatment were taking conjugated estrogens (CE) or oral contraceptives (OC). Factors associated with uterine maturity were history of spontaneous puberty and duration and type of HRT, with estradiol-based treatment being the most effective. The age at starting HRT was not a critical factor.<br />Conclusions: Women with TS may develop a normal uterus even at a late start of HRT given adequate duration of treatment and regardless of karyotype.
- Subjects :
- Adolescent
Adult
Age Factors
Contraceptives, Oral therapeutic use
Cross-Sectional Studies
Estrogen Replacement Therapy
Estrogens therapeutic use
Estrogens, Conjugated (USP) therapeutic use
Female
Humans
Logistic Models
Menarche
Middle Aged
Turner Syndrome genetics
Ultrasonography
Uterus diagnostic imaging
Turner Syndrome complications
Uterus anatomy & histology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 151
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 17961700
- Full Text :
- https://doi.org/10.1016/j.jpeds.2007.04.031