Back to Search
Start Over
Chronic inflammation and T cell zeta-chain downregulation in hemodialysis patients.
- Source :
-
American journal of nephrology [Am J Nephrol] 2008; Vol. 28 (1), pp. 152-7. Date of Electronic Publication: 2007 Oct 19. - Publication Year :
- 2008
-
Abstract
- Background: Clinical and experimental data indicate a deficient immune response in hemodialysis (HD) patients. zeta-Chain phosphorylation is an early and central event in the process that follows antigen recognition by the T cell antigen receptor (TCR). T cell zeta-chain is downregulated in many chronic inflammatory states, such as cancer, autoimmune disease and chronic infection. HD is also characterized as a chronic inflammatory state. The aim of the present study was to evaluate T cell zeta-chain expression in HD patients.<br />Patients and Methods: Thirty-three stable HD patients and 30 healthy volunteers were enrolled into the study. T cell count, the percentage of zeta-chain-positive T cells, as well as T cell zeta-chain mean fluorescence intensity (MFI) were evaluated with flow cytometry. The inflammatory markers C-reactive protein, interleukin-6 and tumor necrosis factor-alpha were measured in the serum by means of ELISA.<br />Results: All the evaluated markers of inflammation were increased in HD patients. In these patients, T cell zeta-chain MFI was decreased. CD3-epsilon MFI did not differ between the two groups indicating that among the TCR complex constituents, zeta-chain is selectively downregulated.<br />Conclusions: HD is a state of chronic inflammation. Like in other pathological chronic inflammatory conditions, T cell zeta-chain is downregulated in HD patients. Since zeta-chain plays a key role in the transduction of the signal that follows antigen recognition by the TCR, its downregulation could be responsible for the deficient cellular immune response observed in HD patients.<br /> ((c) 2007 S. Karger AG, Basel.)
- Subjects :
- Aged
C-Reactive Protein metabolism
CD3 Complex metabolism
Chronic Disease
Down-Regulation immunology
Female
Humans
Kidney Failure, Chronic therapy
Lymphocyte Count
Male
Middle Aged
Phosphorylation
Renal Dialysis
Inflammation immunology
Kidney Failure, Chronic immunology
Membrane Proteins metabolism
Receptors, Antigen, T-Cell metabolism
T-Lymphocytes immunology
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9670
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 17951997
- Full Text :
- https://doi.org/10.1159/000110020