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Genetic variation in ABCA1 predicts ischemic heart disease in the general population.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2008 Jan; Vol. 28 (1), pp. 180-6. Date of Electronic Publication: 2007 Oct 19. - Publication Year :
- 2008
-
Abstract
- Objective: We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population.<br />Methods and Results: We genotyped 9259 individuals from the Danish general population followed for 25 years. Two SNPs (V771M and V825I) were previously associated with increases in HDL-C, 1 (R1587K) with decreased HDL-C, whereas 3 (R219K, I883M and E1172D) did not affect HDL-C levels. Despite this, 5 out of 6 SNPs (V771M, V825I, I883M, E1172D, R1587K) predicted increased risk of IHD. Similar results were obtained in a verification sample with 932 IHD cases versus 7999 controls. A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.<br />Conclusions: We show that 3 of 6 nonsynonymous SNPs in ABCA1 predict risk of IHD in the general population.
- Subjects :
- ATP Binding Cassette Transporter 1
Adult
Case-Control Studies
Denmark
Female
Follow-Up Studies
Humans
Linkage Disequilibrium
Male
Middle Aged
Odds Ratio
ATP-Binding Cassette Transporters genetics
Genetic Predisposition to Disease genetics
Myocardial Ischemia genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 17951323
- Full Text :
- https://doi.org/10.1161/ATVBAHA.107.153858