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Impulsive choice in a rodent model of attention-deficit/hyperactivity disorder.
- Source :
-
Behavioural brain research [Behav Brain Res] 2008 Feb 11; Vol. 187 (1), pp. 146-52. Date of Electronic Publication: 2007 Sep 14. - Publication Year :
- 2008
-
Abstract
- The spontaneously hypertensive rat (SHR) has been studied extensively as a purported rodent model of attention-deficit/hyperactivity disorder (ADHD). Because ADHD in humans is partially defined by marked impulsivity, SHRs, if a valid model of ADHD, ought to behave more impulsively than their normotensive parent strain, Wistar Kyoto (WKY). This prediction was evaluated in two experiments that employed an intertemporal choice procedure in which SHRs and WKYs made repeated choices between a single food pellet delivered immediately and three food pellets delivered after a delay. Four or five delays were investigated (1, 3, 6, 12 and 24s); the experiments differed in the manner in which the delays were experienced. In Experiment 1, the delay values changed after each session and were presented in ascending then descending order. SHRs chose more small/immediate reinforcers than WKYs at the longest delays during the ascending series and at nearly all delays during the descending series. In Experiment 2, the delay values remained in effect for several sessions and were presented in random order. Again, the SHRs chose more small/immediate reinforcers than the WKYs at the longest delays. Thus, in the present study, the SHRs were shown to be more impulsive than the WKYs as defined by preference for smaller, immediate reinforcers over larger, delayed ones in an intertemporal choice procedure.
- Subjects :
- Algorithms
Animals
Attention Deficit Disorder with Hyperactivity genetics
Conditioning, Operant physiology
Data Interpretation, Statistical
Impulsive Behavior genetics
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Reinforcement, Psychology
Attention Deficit Disorder with Hyperactivity psychology
Choice Behavior physiology
Impulsive Behavior psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 187
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 17950930
- Full Text :
- https://doi.org/10.1016/j.bbr.2007.09.008