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Valproate (depakine-chrono) in the acute treatment of outpatients with generalized anxiety disorder without psychiatric comorbidity: randomized, double-blind placebo-controlled study.
- Source :
-
European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2008 Mar; Vol. 23 (2), pp. 109-14. Date of Electronic Publication: 2007 Oct 22. - Publication Year :
- 2008
-
Abstract
- Objective: Anxiety disorders are highly prevalent in population of European countries. However, the effect of Valproate (depakine-chrono) on generalized anxiety disorder (GAD) has not been studied in a double-blind placebo-controlled design.<br />Method: Eighty patients (all men) were washout from the all medications. Each patient was randomized to receive either depakine-chrono (40 patients) for 6 weeks or matched placebo (40 patients) in a double-blind manner. Eligible participants, in addition to meeting the DSM-IV criteria for GAD and having a minimum score of 25 and more on the Hamilton Anxiety Scale, were required to be between 18 and 65 years. Response was defined as a 50% reduction in the Hamilton anxiety scale score. Response and side effects with depakine-chrono and placebo were compared by using analysis of variance (ANOVA) and chi-square tests. Six patients did not return for at least one subsequent assessment, leaving 74 patients (36 taking depakine-chrono and 38 taking placebo) in the valuables study group.<br />Results: Twenty six of the 36 depakine-chrono-treated participants responded by 6 weeks, versus six of the 38 placebo-treated participants (p<0.001). The most common and problematic side effect in the depakine-chrono group was dizziness and nausea.<br />Conclusions: The authors believe this to be the first double-blind placebo-controlled randomization study to test the efficacy of a depakine-chrono in the management of anxiety disorders. They need to be replicated in a larger study group.
- Subjects :
- Acute Disease
Adult
Anticonvulsants adverse effects
Anxiety Disorders diagnosis
Anxiety Disorders psychology
Azerbaijan
Diagnostic and Statistical Manual of Mental Disorders
Double-Blind Method
Drug Administration Schedule
Humans
Male
Middle Aged
Personality Inventory
Treatment Outcome
Valproic Acid adverse effects
Anticonvulsants administration & dosage
Anxiety Disorders drug therapy
Valproic Acid administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0924-9338
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Publication Type :
- Academic Journal
- Accession number :
- 17945470
- Full Text :
- https://doi.org/10.1016/j.eurpsy.2007.08.001