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Hepatitis C virus infection in Italian patients with fibromyalgia.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2008 Jan; Vol. 27 (1), pp. 101-3. Date of Electronic Publication: 2007 Oct 18. - Publication Year :
- 2008
-
Abstract
- We evaluated the prevalence of hepatitis C virus (HCV) infection in Italian patients suffering from fibromyalgia (FM), in comparison with patients affected by non-HCV related rheumatic degenerative disorders. Consecutive patients with FM and a statistically comparable group of patients suffering from peripheral osteoarthritis (OA) or sciatica due to L4-L5 or L5-S1 herniated disc were tested for HCV infection with a third-generation microparticle enzyme immunoassay (MEIA). In the positive cases, a third-generation recombinant immunoblot assay (RIBA) confirmatory test and serum HCV-RNA test were performed. Fisher's exact test was performed to compare the prevalence of HCV infection (MEIA- and RIBA-positive results) obtained in the two enrolled groups. Enrolled were 152 subjects suffering from FM and 152 patients with peripheral OA or sciatica. Anti-HCV antibodies were found in 7/152 (4.6%) patients suffering from FM and in 5/152 (3.3%) of control subjects. No statistically significant differences in HCV prevalence were detected between cases and controls. Our present report does not confirm previous data indicating an increased prevalence of HCV in FM patients and does not seem to support a significant pathogenetic role of HCV under this condition.
- Subjects :
- Adult
Aged
Aged, 80 and over
Comorbidity
Female
Fibromyalgia diagnosis
Fibromyalgia virology
Hepacivirus immunology
Hepatitis C diagnosis
Hepatitis C virology
Humans
Immunoblotting
Immunoenzyme Techniques
Intervertebral Disc Displacement epidemiology
Intervertebral Disc Displacement virology
Italy epidemiology
Male
Middle Aged
Osteoarthritis epidemiology
Osteoarthritis virology
Prevalence
Prospective Studies
Sciatica epidemiology
Sciatica virology
Ambulatory Care Facilities
Fibromyalgia epidemiology
Hepacivirus isolation & purification
Hepatitis C epidemiology
Outpatients
Subjects
Details
- Language :
- English
- ISSN :
- 0770-3198
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 17943229
- Full Text :
- https://doi.org/10.1007/s10067-007-0737-4