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Dietary lipids in early development: relevance to obesity, immune and inflammatory disorders.
- Source :
-
Current opinion in endocrinology, diabetes, and obesity [Curr Opin Endocrinol Diabetes Obes] 2007 Oct; Vol. 14 (5), pp. 359-64. - Publication Year :
- 2007
-
Abstract
- Purpose of Review: Regardless of social, cultural and behavioural environments, obesity is usually caused by an energy intake above requirements, which is accommodated by the accumulation of triacylglycerols. The composition of dietary fat impacts tissue fatty acids, which are important modulators of multiple cell functions, including differentiation, lipogenesis, lipolysis and the generation of inflammatory mediators. This review focuses on the possible contribution of fatty acids to the link between obesity and inflammation in young children.<br />Recent Findings: Adipose tissue is a complex organ that functions to regulate fatty acid balance, clearing and releasing fatty acids, and synthesizing protein and signaling molecules that act as local and distant inflammatory mediators. Obesity, even in young children, is associated with increased circulating inflammatory mediators. As a result of changes in dietary fat compositions, infants are exposed to high n-6, saturated and trans fatty acids and low n-3 fatty acids. Saturated and trans fatty acids increase and n-3 fatty acids decrease many metabolic and inflammatory changes that accompany diet-induced triacylglycerol storage. High linoleic acid is associated with increased oxidative stress.<br />Summary: There is a biological reason to consider that dietary fatty acids may contribute to oxidative stress and heightened inflammatory responses in young children.
- Subjects :
- Adipose Tissue immunology
Adipose Tissue physiopathology
Child
Child Development
Dietary Fats immunology
Dietary Fats metabolism
Dietary Fats standards
Energy Intake immunology
Fatty Acids adverse effects
Fatty Acids immunology
Fatty Acids pharmacology
Fatty Acids, Monounsaturated pharmacology
Homeostasis
Humans
Immune System Diseases metabolism
Infant
Inflammation etiology
Inflammation immunology
Inflammation physiopathology
Inflammation Mediators adverse effects
Inflammation Mediators pharmacokinetics
Obesity immunology
Obesity metabolism
Oxidative Stress immunology
Trans Fatty Acids adverse effects
Trans Fatty Acids immunology
Trans Fatty Acids pharmacology
Triglycerides adverse effects
Triglycerides biosynthesis
Triglycerides immunology
Dietary Fats adverse effects
Immune System Diseases etiology
Obesity etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1752-2978
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current opinion in endocrinology, diabetes, and obesity
- Publication Type :
- Academic Journal
- Accession number :
- 17940463
- Full Text :
- https://doi.org/10.1097/MED.0b013e3282be90b9