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A phase II trial of bortezomib and prednisone for castration resistant metastatic prostate cancer.
- Source :
-
The Journal of urology [J Urol] 2007 Dec; Vol. 178 (6), pp. 2378-83; discussion 2383-4. Date of Electronic Publication: 2007 Oct 22. - Publication Year :
- 2007
-
Abstract
- Purpose: We defined the antitumor effects of bortezomib alone and in combination with prednisone in patients with progressive, castration resistant metastatic prostate cancer.<br />Materials and Methods: A total of 30 men with progressive castration resistant disease were treated in 2 groups. Cohort 1 received 1.5 mg/m2 bortezomib intravenously twice weekly for 2 cycles (2 weeks on and 1 week off), followed by 1.6 mg/m2 weekly (4 weeks on and 2 weeks off). Prednisone (10 mg) was given orally throughout. Cohort 2 comprised patients with limited chemotherapy exposure who received a decreased dose of bortezomib (1.3 mg/m2) during the induction period with prednisone added only at disease progression. The primary end point was no evidence of disease progression at 12 weeks, defined as no increase in prostate specific antigen from baseline and no radiographic progression. Interleukin-6 was assessed to correlate with antitumor effects.<br />Results: One of 24 evaluable patients (4%) achieved the primary end point. In cohort 1, 18 patients were treated, 13 were evaluable for response and 4 discontinued treatment due to toxicities, including 3 before attaining the point of being evaluable. No patient achieved the primary end point. In cohort 2, 12 patients were treated and 11 were evaluable for response. Toxicity was slightly mitigated compared with that in cohort 1. One patient achieved the primary end point. Interleukin-6 did not correlate with posttreatment prostate specific antigen changes in either cohort.<br />Conclusions: Although interleukin-6 and other pathways regulated by nuclear factor-kappa B may be legitimate targets, treatment with bortezomib alone and with prednisone does not appear to have significant antitumor effects in patients with castration resistant metastatic prostate cancer.
- Subjects :
- Administration, Oral
Aged
Aged, 80 and over
Boronic Acids administration & dosage
Boronic Acids adverse effects
Bortezomib
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Humans
Injections, Intravenous
Male
Maximum Tolerated Dose
Middle Aged
Neoplasm Staging
Orchiectomy
Prednisone administration & dosage
Prednisone adverse effects
Prostate-Specific Antigen drug effects
Prostatic Neoplasms mortality
Prostatic Neoplasms pathology
Pyrazines administration & dosage
Pyrazines adverse effects
Risk Assessment
Survival Rate
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Neoplasm Invasiveness pathology
Prostate-Specific Antigen blood
Prostatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3792
- Volume :
- 178
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 17936848
- Full Text :
- https://doi.org/10.1016/j.juro.2007.08.015