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[Subarachnoid haemorrhage: epidemiology, genomic, clinical presentation].
- Source :
-
Annales francaises d'anesthesie et de reanimation [Ann Fr Anesth Reanim] 2007 Nov; Vol. 26 (11), pp. 943-7. Date of Electronic Publication: 2007 Nov 01. - Publication Year :
- 2007
-
Abstract
- Subarachnoid haemorrhage (SAH) accounts for 1 to 7% of all strokes. In France, the range of incidence of SAH varies between 3 and 8/100,000 inhabitants. Global mortality lies around 40%, including 70% during the first week. The size of more than 90% of all aneurysms is less than 10 mm. In more than 90% of the patients; SAH is sporadic and a familial screening is warranted only after SAH occurring in 2 first-degree relatives. The main risk factors of SAH are tobacco, arterial hypertension and alcohol abuse. Genetic susceptibility may exist: it could involve several genes, the expression of which would characterize pathophysiological pathways implicated in the disease. This could be identified using genomic technique of microarrays, which could explore all the genome, simply using a sample of peripheral venous blood. For example, in the future, this approach could help to identify patients who are at high risk to develop vasospasm after SAH.
- Subjects :
- Alcoholism complications
France epidemiology
Global Health
Humans
Hypertension complications
Incidence
Intracranial Aneurysm epidemiology
Mass Screening methods
Nuclear Family
Risk Factors
Stroke epidemiology
Subarachnoid Hemorrhage mortality
Subarachnoid Hemorrhage physiopathology
Subarachnoid Hemorrhage epidemiology
Subarachnoid Hemorrhage genetics
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6623
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Annales francaises d'anesthesie et de reanimation
- Publication Type :
- Academic Journal
- Accession number :
- 17935939
- Full Text :
- https://doi.org/10.1016/j.annfar.2007.09.006