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Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive protein (<2 mg/L) and low-density lipoprotein cholesterol (< 70 mg/dl) targets in patients with type 2 diabetes mellitus (from the ANDROMEDA study).
- Source :
-
The American journal of cardiology [Am J Cardiol] 2007 Oct 15; Vol. 100 (8), pp. 1245-8. Date of Electronic Publication: 2007 Aug 02. - Publication Year :
- 2007
-
Abstract
- Decreasing C-reactive protein (CRP) in addition to decreasing low-density lipoprotein (LDL) cholesterol may further decrease coronary heart disease risk. The effects of rosuvastatin compared with atorvastatin in achieving a combined target of LDL cholesterol <70 mg/dl and CRP <2 mg/L in 509 patients with type 2 diabetes mellitus was evaluated. CRP decreased significantly versus baseline in both treatment groups. Significantly more patients treated with rosuvastatin achieved the combined end point of LDL cholesterol <70 mg/dl and CRP <2 mg/L compared with atorvastatin by the end of the study period (58% vs 37%; p <0.001 vs atorvastatin). In conclusion, CRP was effectively decreased in patients with type 2 diabetes receiving rosuvastatin or atorvastatin, whereas rosuvastatin decreased LDL cholesterol significantly more than atorvastatin.
- Subjects :
- Atorvastatin
C-Reactive Protein drug effects
C-Reactive Protein metabolism
Cholesterol, LDL blood
Cholesterol, LDL drug effects
Double-Blind Method
England
Female
Fluorobenzenes administration & dosage
Heptanoic Acids administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Hypercholesterolemia blood
Hypercholesterolemia complications
Male
Middle Aged
North Carolina
Pyrimidines administration & dosage
Pyrroles administration & dosage
Rosuvastatin Calcium
Sulfonamides administration & dosage
Treatment Outcome
Diabetes Mellitus, Type 2
Fluorobenzenes therapeutic use
Heptanoic Acids therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hypercholesterolemia drug therapy
Pyrimidines therapeutic use
Pyrroles therapeutic use
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 100
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 17920365
- Full Text :
- https://doi.org/10.1016/j.amjcard.2007.05.044