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Transmembrane proteins of tight junctions.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2008 Mar; Vol. 1778 (3), pp. 588-600. Date of Electronic Publication: 2007 Sep 04. - Publication Year :
- 2008
-
Abstract
- Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes, and signal transduction, acting as a multifunctional complex in vertebrate epithelial and endothelial cells. The identification and characterization of the transmembrane proteins of tight junctions, claudins, junctional adhesion molecules (JAMs), occludin and tricellulin, have led to insights into the molecular nature of tight junctions. We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases.
- Subjects :
- Animals
Cell Adhesion Molecules chemistry
Cell Adhesion Molecules physiology
Humans
Junctional Adhesion Molecules
MARVEL Domain Containing 2 Protein
Membrane Proteins chemistry
Membrane Proteins genetics
Models, Biological
Molecular Structure
Mutation
Occludin
Tight Junctions chemistry
Membrane Proteins physiology
Tight Junctions physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1778
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 17916321
- Full Text :
- https://doi.org/10.1016/j.bbamem.2007.08.017