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Effects of oral administration of furosemide and torsemide in healthy dogs.
- Source :
-
American journal of veterinary research [Am J Vet Res] 2007 Oct; Vol. 68 (10), pp. 1058-63. - Publication Year :
- 2007
-
Abstract
- Objective: To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs.<br />Animals: 8 mixed-breed dogs.<br />Procedures: In a crossover study, furosemide (2 mg/kg), torsemide (0.2 mg/kg), or placebo (bifidobacterium [1 mg/kg]) was administered orally to each dog every 12 hours for 14 days. Blood and urine samples were collected before the study (baseline data) and at intervals on the 1st (short-term administration) and 14th day (long-term administration) of treatment for assessment of urine volume and specific gravity and selected clinicopathologic variables including BUN, creatinine, and aldosterone concentrations, and creatinine clearance.<br />Results: Compared with the baseline value, short-term administration of furosemide or torsemide immediately increased urine volume significantly; after long-term administration of either drug, urine specific gravity decreased significantly. Compared with the effect of placebo, the 24-hour urine volume was significantly increased after short-term administra-tion of furosemide or torsemide. In addition, it was significantly increased after long-term administration of torsemide, compared with that of short-term administration. Long-term administration of furosemide or torsemide increased the BUN and plasma creatinine con-centrations, compared with the baseline value. Compared with the baseline value, plasma aldosterone concentration was significantly increased after long-term administration of either drug and was significantly higher after torsemide treatment than after furosemide treatment.<br />Conclusions and Clinical Relevance: In dogs, diuretic resistance developed after 14 days of furosemide, but not torsemide, administration; however, both loop diuretics were associated with increased BUN and plasma creatinine concentrations, compared with values before treatment.
- Subjects :
- Administration, Oral
Animals
Blood Proteins drug effects
Blood Proteins metabolism
Blood Urea Nitrogen
Body Weight
Creatinine blood
Diuretics administration & dosage
Female
Furosemide administration & dosage
Hematocrit
Male
Placebos
Sulfonamides administration & dosage
Torsemide
Urine physiology
Diuretics pharmacology
Dogs physiology
Furosemide pharmacology
Sulfonamides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9645
- Volume :
- 68
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 17916010
- Full Text :
- https://doi.org/10.2460/ajvr.68.10.1058