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Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients.
Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients.
- Source :
-
Neuromolecular medicine [Neuromolecular Med] 2007; Vol. 9 (3), pp. 249-54. - Publication Year :
- 2007
-
Abstract
- High plasma homocysteine levels have been observed in Parkinson's disease (PD) patients treated with levodopa. In this study, we investigated the effects of C677T and A1298C MTHFR polymorphisms, in association with L-DOPA daily dose and vitamin status, on hyperhomocysteinemia development in PD patients. Plasma homocysteine and folate/vitamin B12 levels were assayed in 49 L-DOPA-treated PD patients, and compared with those of 86 healthy subjects. Genotyping for MTHFR polymorphisms was carried out by DG-DGGE. Homocysteine levels were significantly higher in patients than in controls (16.3 +/- 5.7 vs. 11.7 +/- 2.7 micromol/l, P < 0.01). No significant differences were found between patients and controls with regard to folate/vitamin B12 levels, and MTHFR allele distribution. The TT+AA genotype was significantly more frequent in PD patients than in controls (32.5% vs. 17.4%, P < 0.05), but not associated with an increased risk for PD (OR = 2.3, CI = 1.0-5.2). Further, patients carrier of this genotype exhibited a mild hyperhomocysteinemia (22.1 +/- 4.9 micromol/l), while a protective effect was observed in patients having the CC+AA genotype (11.2 +/- 1.6 micromol/l; OR = 0.19, CI = 0.06-0.59). Interestingly, homocysteine levels were also moderately increased in patients with CT heterozygous genotype, in the context of either AA or AC (14.5 +/- 3.6 micromol/l), in comparison to subjects with the CC + AA genotype. Finally, we did not find any significant association of combined C677T and A1298C MTHFR polymorphisms with an increased risk for hyperhomocysteinemia in PD patients. A better understanding of the role of homocysteine and MTHFR genotypes in PD is needed to reveal novel approaches for disease management.
- Subjects :
- Aged
Female
Folic Acid blood
Humans
Hyperhomocysteinemia genetics
Male
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Middle Aged
Parkinson Disease enzymology
Parkinson Disease genetics
Vitamin B 12 blood
Antiparkinson Agents therapeutic use
Homocysteine blood
Hyperhomocysteinemia enzymology
Levodopa therapeutic use
Methylenetetrahydrofolate Reductase (NADPH2) physiology
Parkinson Disease drug therapy
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1535-1084
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuromolecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17914182
- Full Text :
- https://doi.org/10.1007/s12017-007-8006-x