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Expression of MDR1 in epithelial ovarian cancer and its association with disease progression.
- Source :
-
Oncology research [Oncol Res] 2007; Vol. 16 (8), pp. 395-403. - Publication Year :
- 2007
-
Abstract
- The purposes of this study were to analyze MDR1 expression in ovarian tumors prior to chemotherapy, to correlate the expression with p16, IGFs, ERalpha, and BRCA1, and to examine the association of MDR1 expression with ovarian cancer prognosis. A primary ovarian cancer cohort of 206 patients after surgery was followed up. MDR1, IGFs, ERalpha, p16, and BRCA1 expressions were analyzed in ovarian tumor samples using quantitative real-time PCR. MDR1 was detected in 177 of 206 specimens. MDR1 expression was positively correlated with IGFBP3, ERalpha, p16, and BRCA1, but not correlated with IGF-II, age, and other clinicopathological parameters. MDR1 expression significantly elevated the risk for disease progression (p = 0.02), and this association remained statistically significant after controlling for patient age and clinicopathological parameters or other correlated genes. No association was found between MDR1 expression and overall survival. MDR1 expression may be an independent marker for ovarian cancer progression and combination of different agents targeting different molecules may improve the outcome of ovarian cancer treatment and prevent drug resistance.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
BRCA1 Protein genetics
Cyclin-Dependent Kinase Inhibitor p16 genetics
Disease Progression
Drug Resistance, Multiple genetics
Estrogen Receptor alpha genetics
Female
Follow-Up Studies
Humans
Insulin-Like Growth Factor Binding Protein 3 genetics
Insulin-Like Growth Factor II genetics
Middle Aged
Neoplasm Staging
Neoplasms, Cystic, Mucinous, and Serous drug therapy
Neoplasms, Cystic, Mucinous, and Serous metabolism
Neoplasms, Cystic, Mucinous, and Serous surgery
Ovarian Neoplasms drug therapy
Ovarian Neoplasms metabolism
Ovarian Neoplasms surgery
Prognosis
RNA, Messenger genetics
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Treatment Outcome
ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism
Biomarkers, Tumor metabolism
Gene Expression Regulation, Neoplastic
Neoplasms, Cystic, Mucinous, and Serous genetics
Ovarian Neoplasms genetics
RNA, Neoplasm metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0965-0407
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Oncology research
- Publication Type :
- Academic Journal
- Accession number :
- 17913048
- Full Text :
- https://doi.org/10.3727/000000006783980892