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Novel scaffold for cathepsin K inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Nov 15; Vol. 17 (22), pp. 6096-100. Date of Electronic Publication: 2007 Sep 15. - Publication Year :
- 2007
-
Abstract
- Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.
- Subjects :
- Cathepsin K
Humans
Inhibitory Concentration 50
Molecular Structure
Pyrimidines chemistry
Pyrroles chemistry
Recombinant Proteins antagonists & inhibitors
Structure-Activity Relationship
Cathepsins antagonists & inhibitors
Pyrimidines chemical synthesis
Pyrimidines pharmacology
Pyrroles chemical synthesis
Pyrroles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17911019
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.09.047