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Head-to-head comparison of sirolimus- and paclitaxel-eluting stent in the same diabetic patient with multiple coronary artery lesions: a prospective, randomized, multicenter study.
- Source :
-
Diabetes care [Diabetes Care] 2008 Jan; Vol. 31 (1), pp. 15-9. Date of Electronic Publication: 2007 Oct 01. - Publication Year :
- 2008
-
Abstract
- Objective: It is still controversial whether sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) are equally effective in patients with diabetes. In these patients, multiple individual variables may be responsible for neointimal hyperplasia, thus making difficult the comparison of the two drug-eluting stents (DES).<br />Research Design and Methods: We designed a prospective, randomized study to compare the efficacy in prevention of restenosis of SES and PES, both implanted in the same diabetic patient with multiple de novo coronary artery lesions undergoing elective percutaneous coronary intervention. We enrolled 60 patients with diabetes with at least two significant de novo angiographic stenoses in different coronary segments. The primary end point was in-stent late luminal loss (LLL) at 8-month angiographic follow-up.<br />Results: A total of 120 lesions were successfully treated with the randomly assigned DES (SES, n = 60; PES, n = 60). In-stent LLL was lower in the SES than in the PES group (0.26 +/- 0.4 vs. 0.50 +/- 0.6 mm; P = 0.01). Coronary lesions treated with SES presented a reduced in-stent LLL in 40 (68%) patients, while PES resulted in a lower in-stent LLL in 19 (32%) patients (P = 0.0002). At multivariable analysis, the type of DES implanted was the only independent predictor of in-stent LLL (odds ratio 2.3 [95% CI 1.1-5.0]; P = 0.03).<br />Conclusions: SES directly compared with PES in the same diabetic patient is associated with a decrease in the extent of in-stent LLL at 8 months, suggesting a reduced risk of restenosis.
- Subjects :
- Aged
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Antineoplastic Agents administration & dosage
Antineoplastic Agents therapeutic use
Coronary Angiography
Coronary Disease drug therapy
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies drug therapy
Female
Humans
Male
Middle Aged
Paclitaxel administration & dosage
Prospective Studies
Sirolimus administration & dosage
Coronary Disease surgery
Coronary Restenosis prevention & control
Diabetic Angiopathies surgery
Drug-Eluting Stents
Paclitaxel therapeutic use
Sirolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 17909090
- Full Text :
- https://doi.org/10.2337/dc07-1377