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Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential.
- Source :
-
Vaccine [Vaccine] 2007 Oct 23; Vol. 25 (43), pp. 7530-9. Date of Electronic Publication: 2007 Sep 12. - Publication Year :
- 2007
-
Abstract
- The existing vaccines against influenza are based on the generation of neutralizing antibody primarily directed against surface proteins - hemagglutinin and neuraminidase. In this work, we have computationally defined conserved T cell epitopes of proteins of influenza virus H5N1 to help in the design of a vaccine with haplotype specificity for a target population. The peptides from the proteome of H5N1 virus which are predicted to bind to different HLAs, do not show similarity with peptides of human proteome and are also identified to be generated by proteolytic cleavage. These peptides could be made use of in the design of either a DNA vaccine or a subunit vaccine against influenza.
- Subjects :
- Animals
Epitopes, B-Lymphocyte immunology
Epitopes, B-Lymphocyte metabolism
Epitopes, T-Lymphocyte chemistry
Epitopes, T-Lymphocyte metabolism
Histocompatibility Antigens Class I metabolism
Histocompatibility Antigens Class II metabolism
Humans
Influenza A Virus, H5N1 Subtype metabolism
Models, Molecular
Peptides immunology
Peptides metabolism
Protein Binding
Proteome analysis
Proteome immunology
Epitopes, T-Lymphocyte immunology
Influenza A Virus, H5N1 Subtype immunology
Influenza Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 25
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 17900763
- Full Text :
- https://doi.org/10.1016/j.vaccine.2007.08.044