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Scaling-up co-trimoxazole prophylaxis in HIV-exposed and HIV-infected children in high HIV-prevalence countries.
- Source :
-
The Lancet. Infectious diseases [Lancet Infect Dis] 2007 Oct; Vol. 7 (10), pp. 686-93. - Publication Year :
- 2007
-
Abstract
- Co-trimoxazole (trimethoprim-sulfamethoxazole) is a widely available antibiotic that substantially reduces HIV-related morbidity and mortality in both adults and children. Prophylaxis with co-trimoxazole is a recommended intervention of proven benefit that could serve not only as an initial step towards improving paediatric care in young children with limited access to antiretroviral treatment, but also as an important complement to antiretroviral therapy in resource-limited settings. Despite co-trimoxazole's known clinical benefits, the potential operational benefits, and favourable recommendations by WHO, UNAIDS, and UNICEF, its routine use in developing countries--particularly sub-Saharan Africa--has remained limited. Out of an estimated 4 million children in need of co-trimoxazole prophylaxis (HIV-exposed and HIV-infected), only 4% are currently receiving this intervention. We discuss some of the major barriers preventing the scale-up of co-trimoxazole prophylaxis for children in countries with a high prevalence of HIV and propose specific actions required to tackle these challenges.
- Subjects :
- AIDS-Related Opportunistic Infections mortality
Adolescent
Anti-Infective Agents administration & dosage
Chemoprevention
Child
Child, Preschool
Developing Countries
HIV Infections complications
HIV Infections mortality
Health Policy
Humans
Infant
Infant, Newborn
Prevalence
Trimethoprim, Sulfamethoxazole Drug Combination administration & dosage
AIDS-Related Opportunistic Infections prevention & control
Anti-Infective Agents therapeutic use
HIV Infections epidemiology
Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1473-3099
- Volume :
- 7
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Lancet. Infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 17897611
- Full Text :
- https://doi.org/10.1016/S1473-3099(07)70239-6