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Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2007 Dec 05; Vol. 144B (8), pp. 1027-33. - Publication Year :
- 2007
-
Abstract
- Context: Obsessive-Compulsive Disorder (OCD) is a debilitating illness with putative glutamatergic abnormalities. Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required.<br />Objectives: This study examines SLC1A1 as a candidate gene for OCD and explores gender influences. It was hypothesized that a significant association between SLC1A1 and OCD would be replicated in an independent sample of males but not females.<br />Design: Family-based association candidate gene study.<br />Setting: Participants were recruited from tertiary care OCD specialty clinics.<br />Participants: OCD probands and their first degree relatives.<br />Main Outcomes Measures: Association of OCD with genotypes of single nucleotide polymorphism (SNP) markers and related haplotypes.<br />Results: Association between OCD and the three-marker haplotype rs12682807/ rs2072657/ rs301430, with overtransmission of A/T/T, was observed in both genders combined (global P = 0.0015) and in males (global P = 0.0031). Single-marker associations with OCD in the region (rs3780412 and rs2228622) demonstrated modest significance (permuted P = 0.045).<br />Conclusions: This study identifies a significant association between the SLC1A1 glutamate transporter gene and OCD in a haplotype overlapping with that recently reported.<br /> (2007 Wiley-Liss, Inc.)
- Subjects :
- Adolescent
Age Distribution
Age of Onset
Child
Chromosome Mapping
Female
Gene Frequency
Genetic Predisposition to Disease genetics
Genotype
Haplotypes genetics
Humans
Linkage Disequilibrium genetics
Male
Obsessive-Compulsive Disorder diagnosis
Sex Distribution
Excitatory Amino Acid Transporter 3 genetics
Obsessive-Compulsive Disorder genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1552-485X
- Volume :
- 144B
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 17894418
- Full Text :
- https://doi.org/10.1002/ajmg.b.30533