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Transcript profile and localization of Wnt signaling-related molecules in human endometrium.

Authors :
Cheng CW
Smith SK
Charnock-Jones DS
Source :
Fertility and sterility [Fertil Steril] 2008 Jul; Vol. 90 (1), pp. 201-4. Date of Electronic Publication: 2007 Sep 24.
Publication Year :
2008

Abstract

The mRNAs encoding several Wnt ligands, Frizzled receptors, and Wnt antagonists were detected in human endometrium, including SFRP1; the levels of SFRP1 mRNA were higher in the proliferative phase of the menstrual cycle and increased in endometriotic tissue compared with control eutopic endometrium, and they were detected in both glandular and stromal cells but were more abundant in the stroma. Our results suggest that Wnt signaling could function in normal endometrial physiology and the the Wnt signalling inhibitor SFRP1 might play a role in endometrial growth and endometriosis development.

Details

Language :
English
ISSN :
1556-5653
Volume :
90
Issue :
1
Database :
MEDLINE
Journal :
Fertility and sterility
Publication Type :
Academic Journal
Accession number :
17889861
Full Text :
https://doi.org/10.1016/j.fertnstert.2007.05.077