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Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study).
- Source :
-
The Journal of pediatrics [J Pediatr] 2007 Oct; Vol. 151 (4), pp. 347-51, 351.e1-2. Date of Electronic Publication: 2007 Jul 12. - Publication Year :
- 2007
-
Abstract
- Objective: To investigate the potential effect of modification by maternal allergic status on the relationship between breast-feeding duration and infant atopic manifestations in the first 2 years of life.<br />Study Design: Data from 2705 infants of the KOALA Birth Cohort Study (The Netherlands) were analyzed. The data were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Total and specific immunoglobulin E measurements were performed on venous blood samples collected during home visits at age 2 years. Relationships were analyzed using logistic regression analyses.<br />Results: Longer duration of breast-feeding was associated with a lower risk for eczema in infants of mothers without allergy or asthma (P(trend) = .01) and slightly lower risk in those of mothers with allergy but no asthma (P(trend) = .14). There was no such association for asthmatic mothers (P(trend) = .87). Longer breast-feeding duration decreased the risk of recurrent wheeze independent of maternal allergy (P(trend) = .02) or asthma status (P(trend) = .06).<br />Conclusions: Our findings show that the relationship between breast-feeding and infant eczema in the first 2 years of life is modified by maternal allergic status. The protective effect of breast-feeding on recurrent wheeze may be associated with protection against respiratory infections.
- Subjects :
- Asthma immunology
Dermatitis, Atopic epidemiology
Dermatitis, Atopic immunology
Eczema epidemiology
Eczema immunology
Eczema prevention & control
Female
Humans
Hypersensitivity immunology
Immunoglobulin E blood
Infant
Infant, Newborn
Logistic Models
Netherlands epidemiology
Pregnancy
Prospective Studies
Recurrence
Respiratory Sounds immunology
Risk
Time Factors
Asthma epidemiology
Breast Feeding
Dermatitis, Atopic prevention & control
Hypersensitivity epidemiology
Mothers statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 151
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 17889066
- Full Text :
- https://doi.org/10.1016/j.jpeds.2007.03.022