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Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.
- Source :
-
Neuroreport [Neuroreport] 2007 Oct 08; Vol. 18 (15), pp. 1567-70. - Publication Year :
- 2007
-
Abstract
- Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr+Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.
- Subjects :
- Adult
Amino Acid Substitution genetics
Amino Acid Substitution physiology
Aspartic Acid metabolism
Creatine metabolism
Female
Genotype
Humans
Magnetic Resonance Spectroscopy
Male
Methionine physiology
Phosphocreatine metabolism
Psychiatric Status Rating Scales
Valine physiology
Bipolar Disorder genetics
Bipolar Disorder metabolism
Brain-Derived Neurotrophic Factor genetics
Brain-Derived Neurotrophic Factor physiology
Energy Metabolism physiology
Polymorphism, Genetic physiology
Prefrontal Cortex metabolism
Prefrontal Cortex physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 18
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 17885603
- Full Text :
- https://doi.org/10.1097/WNR.0b013e3282ef7082