Dried blood spots versus sera for detection of rubella virus-specific immunoglobulin M (IgM) and IgG in samples collected during a rubella outbreak in Peru.

Authors :: Helfand RF
Cabezas C
Abernathy E
Castillo-Solorzano C
Ortiz AC
Sun H
Osores F
Oliveira L
Whittembury A
Charles M
Andrus J
Icenogle J
Source :: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2007 Nov; Vol. 14 (11), pp. 1522-5. Date of Electronic Publication: 2007 Sep 19.
Publication Year :: 2007
Abstract: Most persons with rubella virus-specific immunoglobulin M (IgM)- or IgG-positive sera tested positive (98% [n = 178] and 99% [n = 221], respectively) using paired filter paper dried blood spot (DBS) samples, provided that DBS indeterminate results were called positive. For persons with IgM- or IgG-negative sera, 97% and 98%, respectively, were negative using DBS.

Subjects :: Antibodies, Viral immunology
Blood Specimen Collection
Disease Outbreaks
Humans
Immunoglobulin G immunology
Immunoglobulin M immunology
Peru epidemiology
Rubella epidemiology
Rubella immunology
Rubella virology
Sensitivity and Specificity
Serologic Tests
Antibodies, Viral blood
Immunoglobulin G blood
Immunoglobulin M blood
Rubella diagnosis
Rubella virus immunology

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