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Relations between movement disorders and psychopathology under predominantly atypical antipsychotic treatment in adolescent patients with schizophrenia.
- Source :
-
European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2008 Feb; Vol. 17 (1), pp. 44-53. Date of Electronic Publication: 2007 Sep 14. - Publication Year :
- 2008
-
Abstract
- Objective: To examine relations between movement disorders (MD) and psychopathological symptoms in an adolescent population with schizophrenia under treatment with predominantly atypical antipsychotics.<br />Method: MD symptoms and psychopathology were cross-sectionally assessed in 93 patients (aged 19.6 +/- 2.2 years) using Tardive Dyskinesia Rating Scale (TDRS), Abnormal Involuntary Movement Scale (AIMS), Extrapyramidal Symptom Scale (EPS), Barnes Akathisia Scale (BAS), Brief Psychiatric Rating Scale (BPRS) and the Schedule for Assessment of Negative/Positive Symptoms (SANS/SAPS).<br />Results: All patients with MD symptoms (n = 37; 39.8 %) showed pronounced global psychpathological signs (SANS/SAPS, BPRS: p = 0.026, p = 0.033, p = 0.001) with predominant anergia symptoms (p = 0.005) and inclinations toward higher anxiety- and depression-related symptoms (p = 0.051) as well as increased thought disturbance (p = 0.066). Both negative symptoms and anergia showed trends for positive correlations with tardive dyskinesia (p = 0.068; p = 0.065) as well as significant correlations with parkinsonism symptoms (p = 0.036; p = 0.023). Akathisia symptoms correlated significantly with hostile and suspicious symptoms (p = 0.013). A superfactor-analysis revealed four factors supporting the aforementioned results.<br />Conclusion: MD symptoms and psychopathology are in some respects related to each other. Motor symptoms representing on the one hand trait characteristics of schizophrenia might additionally be triggered by antipsychotics and finally co-occur with more residual symptoms within a long-term treatment.
- Subjects :
- Adolescent
Akathisia, Drug-Induced epidemiology
Akathisia, Drug-Induced psychology
Antipsychotic Agents therapeutic use
Brief Psychiatric Rating Scale statistics & numerical data
Cross-Sectional Studies
Dyskinesia, Drug-Induced epidemiology
Dyskinesia, Drug-Induced psychology
Female
Humans
Male
Neurologic Examination drug effects
Psychometrics
Psychopathology
Schizophrenia epidemiology
Akathisia, Drug-Induced diagnosis
Antipsychotic Agents adverse effects
Dyskinesia, Drug-Induced diagnosis
Schizophrenia drug therapy
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1018-8827
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European child & adolescent psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17876506
- Full Text :
- https://doi.org/10.1007/s00787-007-0633-0