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The impact of dengue on liver function as evaluated by aminotransferase levels.
- Source :
-
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2007 Aug; Vol. 11 (4), pp. 407-10. - Publication Year :
- 2007
-
Abstract
- The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A--normal enzyme levels; grade B--increased levels of at least one of the enzymes; grade C--increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D--acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Child
Dengue physiopathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Liver physiopathology
Liver Function Tests
Male
Middle Aged
Severe Dengue enzymology
Severe Dengue physiopathology
Severity of Illness Index
Alanine Transaminase blood
Aspartate Aminotransferases blood
Dengue enzymology
Liver enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1413-8670
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 17873994
- Full Text :
- https://doi.org/10.1590/s1413-86702007000400007