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Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia. Olfactory identification and Wisconsin Card Sorting performance.
- Source :
-
Schizophrenia research [Schizophr Res] 1991 Dec; Vol. 6 (1), pp. 55-65. - Publication Year :
- 1991
-
Abstract
- Schizophrenic patients and normal control subjects took the University of Pennsylvania Smell Identification Test (UPSIT) and Wisconsin Card Sorting Test (WCST) as dual neuropsychological 'probes' of orbitofrontal (OF) and dorsolateral (DL) prefrontal function respectively. Patients were significantly impaired on both tasks compared to controls. UPSIT and WCST performance were uncorrelated in patients but were positively correlated in controls. The lack of correlation found in the patients suggests that the tasks may be tapping independent dysfunctions in schizophrenia reflecting differential impairment in fronto-limbic brain systems. Individual profiles of preserved and impaired performance on the UPSIT and WCST suggested that three schizophrenic patients had OF dysfunction, five had DL dysfunction and seven had a generalized (OF and DL) frontal system dysfunction. The reduced ability of schizophrenic patients to identify odors was largely independent of many deficits or confounds typically associated with schizophrenia and did not appear to be simply a function of generalized deficit. These data are preliminary and require replication with larger samples and validation with other measures of fronto-limbic system dysfunction.
- Subjects :
- Adolescent
Adult
Attention physiology
Female
Humans
Male
Middle Aged
Neurocognitive Disorders diagnosis
Schizophrenia diagnosis
Discrimination Learning physiology
Frontal Lobe physiopathology
Limbic System physiopathology
Neurocognitive Disorders physiopathology
Neurocognitive Disorders psychology
Neuropsychological Tests
Schizophrenia physiopathology
Schizophrenic Psychology
Smell physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0920-9964
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 1786234
- Full Text :
- https://doi.org/10.1016/0920-9964(91)90021-i