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Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2008 May; Vol. 18 (5), pp. 990-6. Date of Electronic Publication: 2007 Sep 12. - Publication Year :
- 2008
-
Abstract
- Several lines of evidence suggest that schizophrenia (SCZ) is associated with disrupted plasticity in the cortex. However, there is little direct neurophysiological evidence of aberrant long-term potentiation (LTP)-like plasticity in SCZ and little human evidence to establish a link between LTP to learning and memory. LTP was evaluated using a neurophysiological paradigm referred to as paired associative stimulation (PAS). PAS involves pairing of median nerve electric stimulation with transcranial magnetic stimulation (TMS) over the contralateral motor cortex (for abductor pollicis brevis muscle activation) delivered at 25-ms interstimulus interval. This pairing was delivered at a frequency of 0.1 Hz for 30 min. LTP was reflected by the change in motor evoked potentials (MEPs) before and after PAS. In addition, motor skill learning was assessed using the rotary pursuit task. Compared with healthy subjects, patients with SCZ demonstrated significant MEP facilitation deficits following PAS and impaired rotary-pursuit motor learning. Across all subjects there was a significant association between LTP and motor skill learning. These data provide evidence for disrupted LTP in SCZ, whereas the association between LTP with motor skill learning suggests that the deficits in learning and memory in SCZ may be mediated through disordered LTP.
- Subjects :
- Adult
Antipsychotic Agents therapeutic use
Attention physiology
Electromyography
Evoked Potentials, Motor physiology
Female
Humans
Male
Median Nerve physiology
Memory physiology
Neuronal Plasticity physiology
Rest physiology
Rotation
Schizophrenia drug therapy
Transcranial Magnetic Stimulation
Association Learning physiology
Long-Term Potentiation physiology
Motor Cortex physiology
Motor Skills physiology
Schizophrenia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 17855721
- Full Text :
- https://doi.org/10.1093/cercor/bhm151