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[Angiogenesis and radiotherapy (vessels, anaemia, oxygen and radiosensitivity)].
- Source :
-
Bulletin du cancer [Bull Cancer] 2007 Jul; Vol. 94 Spec No, pp. S197-202. - Publication Year :
- 2007
-
Abstract
- Oxygen plays a direct role in cell death after exposure to ionizing radiations and tumour hypoxia, favoured by anaemia, is a factor of poor treatment response. Tumour phenotype is directly influenced by tissue oxygenation, inducing tumour cells adaptation to the environment and potential resistance to treatment. The correction of tumour hypoxia can increase treatment response. It is however difficult to directly correlate pO2 and vascularisation. Vessels from angiogenesis get endothelial cells but have lost the functions of normal vessels (receptors, muscles...). The role of angiogenesis has been demonstrated on initial tumour growth and on metastatic potential and regulation. Many pre clinical studies have demonstrated the benefit of combining anti angiogenic compounds and cytotoxic agents (chemotherapy drugs and ionizing radiations). Clinical studies are on going and new evaluation models of treatment response will be necessary.
- Subjects :
- Anemia drug therapy
Angiogenesis Inhibitors therapeutic use
Animals
Combined Modality Therapy methods
Endothelium, Vascular drug effects
Erythropoietin therapeutic use
Humans
Neoplasms blood
Neoplasms blood supply
Neovascularization, Pathologic radiotherapy
Oxygen Consumption
Partial Pressure
Recombinant Proteins
Anemia metabolism
Cell Hypoxia physiology
Neoplasms therapy
Neovascularization, Pathologic drug therapy
Oxygen metabolism
Radiation Tolerance physiology
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6917
- Volume :
- 94 Spec No
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 17846005