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Influence of yeasts and of their constituents on nucleoside uptake in peritoneal murine macrophages.
- Source :
-
FEMS microbiology letters [FEMS Microbiol Lett] 1991 Dec 15; Vol. 69 (1), pp. 5-9. - Publication Year :
- 1991
-
Abstract
- A marked reduction of [3H]-uridine uptake was observed when mouse peritoneal macrophages (pM phi) were exposed to heat-killed Candida albicans or Saccharomyces cerevisiae. By contrast, an increased nucleoside uptake was promoted by yeast products such as zymosan, laminarin, or yeast cell-wall extracts, which are mainly composed of beta-glucans and alpha-mannans. In a search for the active fungal component(s), the uptake process was shown to be differently affected by monosaccharides and polysaccharides. These findings support the view that a specific recognition of a pM phi membrane receptor is mediating the effect of the various substances.
- Subjects :
- Animals
Candida albicans chemistry
Carbohydrates pharmacology
Cells, Cultured
Culture Media
Female
Kinetics
Macrophage Activation drug effects
Macrophages drug effects
Macrophages metabolism
Mice
Peritoneal Cavity
Saccharomyces cerevisiae chemistry
Candida albicans physiology
Macrophages microbiology
Saccharomyces cerevisiae physiology
Uridine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0378-1097
- Volume :
- 69
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEMS microbiology letters
- Publication Type :
- Academic Journal
- Accession number :
- 1783283
- Full Text :
- https://doi.org/10.1016/0378-1097(91)90637-p