Back to Search
Start Over
Novel propeptin analog, propeptin-2, missing two amino acid residues from the propeptin C-terminus loses antibiotic potency.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2007 Aug; Vol. 60 (8), pp. 519-23. - Publication Year :
- 2007
-
Abstract
- A novel inhibitor of prolyl endopeptidase, the propeptin analog propeptin-2 (C105H130N24O(24)), missing two amino acid residues from the propeptin C-terminus was isolated from the fermentation broth of propeptin-producing Microbispora sp. SNA-115 grown using a large inoculum. It shows the same enzyme inhibition activity as propeptin against prolyl endopeptidase (Ki=1.5 microM), but its antimicrobial activity against Mycobacterium phlei is more than 100-fold lower.
- Subjects :
- Actinomycetales growth & development
Amino Acids metabolism
Culture Media metabolism
Enzyme Inhibitors pharmacology
Microbial Sensitivity Tests
Mycobacterium phlei drug effects
Peptides, Cyclic pharmacology
Prolyl Oligopeptidases
Serine Endopeptidases metabolism
Structure-Activity Relationship
Actinomycetales metabolism
Enzyme Inhibitors chemistry
Enzyme Inhibitors metabolism
Peptides, Cyclic chemistry
Peptides, Cyclic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 60
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 17827663
- Full Text :
- https://doi.org/10.1038/ja.2007.66