N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?

Authors :: Akber SF
Source :: Nuklearmedizin. Nuclear medicine [Nuklearmedizin] 1991 Dec; Vol. 30 (6), pp. 294-6.
Publication Year :: 1991
Abstract: The uptake and binding mechanism of biogenic amines in the lungs has been studied extensively with no conclusive results. The competition between N-isopropyl-123I-p-iodo amphetamines (123I-IMP) and propranolol and 123I-IMP and ketamine, in the lungs suggest that the pKa value of the biogenic amines has a significant role to play in the mechanism of uptake and retention of biogenic amines in the lungs.

Subjects :: Animals
Dogs
Hydrogen-Ion Concentration
Iodine Radioisotopes
Iofetamine
Ketamine pharmacology
Lung drug effects
Propranolol pharmacology
Amphetamines pharmacokinetics
Lung metabolism

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