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Atopic dermatitis and Valpha24+ natural killer T cells.
- Source :
-
Skinmed [Skinmed] 2007 Sep-Oct; Vol. 6 (5), pp. 218-20. - Publication Year :
- 2007
-
Abstract
- Objective: Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis. Helper T cells and their cytokines, in addition to IgE and eosinophils, play a major role in the pathogenesis of atopic dermatitis. Natural killer T (NKT) cells may play a role in atopic dermatitis status.<br />Methods: The authors examined the percentage of Valpha24+CD161+ NKT cells and CD3+CD16+ CD56+ NKT cells in peripheral blood from 23 patients with atopic dermatitis aged 8 to 35 years (mean, 21.77+/-2.88 years) and 30 healthy controls aged 18 to 32 years (mean, 24.32+/-2.44 years) by using flow cytometric analysis. The mean percentages of Valpha24+CD161+ NKT cell subtypes in the atopic dermatitis group and the healthy group were 0.29%+/-0.02% and 0.42%+/-0.05%, respectively (P<.001).<br />Results: Percentages of Valpha24+CD161+ NKT cell subtypes are significantly lower in patients with atopic dermatitis than healthy individuals. On the other hand, the CD3+CD16+CD56+ NKT cell subtype does not differ between the groups.<br />Conclusions: The reduction of Valpha24+CD161+ NKT cells subtypes may be involved in the immunopathogenesis of atopic dermatitis.
- Subjects :
- Adolescent
Adult
Antigens, CD analysis
Child
Dermatitis, Atopic blood
Flow Cytometry
Humans
Immunoglobulin E blood
NK Cell Lectin-Like Receptor Subfamily B
Statistics, Nonparametric
Antigens, Surface analysis
Dermatitis, Atopic immunology
Killer Cells, Natural immunology
Lectins, C-Type analysis
Receptors, Antigen, T-Cell, alpha-beta analysis
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9740
- Volume :
- 6
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Skinmed
- Publication Type :
- Academic Journal
- Accession number :
- 17786098
- Full Text :
- https://doi.org/10.1111/j.1540-9740.2007.06458.x