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The association between ankle-brachial index and cardiovascular or all-cause mortality in metabolic syndrome of elderly Chinese.
- Source :
-
Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2007 Jul; Vol. 30 (7), pp. 613-9. - Publication Year :
- 2007
-
Abstract
- The ankle-brachial index (ABI) is a non-invasive, reliable measurement of lower-extremity ischemia. A low ABI is associated with increased risk of coronary heart disease, stroke and death. However, the relationship between ABI and all-cause mortality or cardiovascular disease (CVD) mortality in patients with metabolic syndrome (MetS) has not been well studied. Accordingly, we here investigated the association between ABI and all-cause and CVD mortality in an elderly Chinese population with MetS. A total of 2,274 MetS patients diagnosed under the criteria proposed by the International Diabetes Federation were divided into two groups based on repeated ABI measurement over a period of 13.6 months: ABI<or=0.9 (n=525) and ABI 0.91-1.4 (n=1,749). Each of the baseline characteristics of age, systolic blood pressure, diabetes mellitus morbidity, and smoking history were significantly different between the two groups (p<0.05 or p<0.01). All-cause mortality and CVD mortality decreased gradually as the ABI increased from 0.4 to 1.4. In Cox regression analysis, the relative ratio of all-cause mortality to CVD mortality also showed a tendency to decrease with increasing ABI. In elderly patients with MetS, ABI is one of the most important indexes for determining the possible prognosis and predicting all-cause and CVD mortality. People with relatively older age, higher systolic blood pressure, diabetes mellitus morbidity and smoking history may be at risk of lower ABI (<or=0.9) and higher all-cause and CVD mortality. Our results suggest the urgent need for repeated ABI measurement in clinical practice, both during individual visits and also over time, before diagnosing peripheral artery disease and making a therapeutic decision, especially in certain high-risk populations such as patients with MetS.
- Subjects :
- Aged
Aged, 80 and over
Blood Flow Velocity physiology
Blood Pressure physiology
Cardiovascular Diseases physiopathology
China epidemiology
Cohort Studies
Cross-Sectional Studies
Female
Humans
Longitudinal Studies
Male
Metabolic Syndrome ethnology
Metabolic Syndrome physiopathology
Middle Aged
Retrospective Studies
Risk Factors
Ankle blood supply
Brachial Artery physiology
Cardiovascular Diseases complications
Cardiovascular Diseases mortality
Metabolic Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 0916-9636
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Hypertension research : official journal of the Japanese Society of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 17785929
- Full Text :
- https://doi.org/10.1291/hypres.30.613