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[Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer].
- Source :
-
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] [Zhonghua Yu Fang Yi Xue Za Zhi] 2007 Jun; Vol. 41 Suppl, pp. 39-42. - Publication Year :
- 2007
-
Abstract
- Objective: To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer.<br />Methods: Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR.<br />Results: Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39).<br />Conclusion: IL8-251-A allele might be associated with higher risk of developing gastric cancer.
Details
- Language :
- Chinese
- ISSN :
- 0253-9624
- Volume :
- 41 Suppl
- Database :
- MEDLINE
- Journal :
- Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
- Publication Type :
- Academic Journal
- Accession number :
- 17767856