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Pergolide protects CA1 neurons from apoptosis in a gerbil model of global cerebral ischemia.
- Source :
-
Neurological research [Neurol Res] 2008 Feb; Vol. 30 (1), pp. 92-8. - Publication Year :
- 2008
-
Abstract
- Objective: To investigate the effects of dopamine (DA) receptor agonists and antagonists on neuronal apoptosis in hippocampal CA1 region after forebrain ischemia/reperfusion (I/R) injury in gerbils.<br />Methods: Gerbil forebrain ischemia was induced by occluding bilateral carotid arteries for 5 minutes. The open field test, hematoxylin-eosin staining and in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) methods were used 1, 3 and 7 days after reperfusion. Western blot was used to examine the phosphorylation of c-Jun.<br />Results: Pergolide could significantly reduce the habituation impairments of ischemic gerbils, increase the number of normal neurons and reduce the number of apoptotic neurons in hippocampal CA1 region after reperfusion. SKF38393, SCH23390 and spiperone had no effects on these changes in this transient I/R injury model. Furthermore, pergolide can significantly reduce the phosphorylation of c-Jun induced by transient forebrain ischemia.
- Subjects :
- Analysis of Variance
Animals
Behavior, Animal drug effects
Disease Models, Animal
Exploratory Behavior drug effects
Gerbillinae
In Situ Nick-End Labeling methods
Male
Proto-Oncogene Proteins c-jun metabolism
Time Factors
Apoptosis drug effects
Brain Ischemia drug therapy
Brain Ischemia pathology
Brain Ischemia physiopathology
Dopamine Agonists therapeutic use
Hippocampus pathology
Neurons drug effects
Pergolide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0161-6412
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurological research
- Publication Type :
- Academic Journal
- Accession number :
- 17767807
- Full Text :
- https://doi.org/10.1179/016164107X228688