The possible role of hyperhomocysteinemia on IVF outcome.

Authors :: Pacchiarotti A
Mohamed MA
Micara G
Linari A
Tranquilli D
Espinola SB
Aragona C
Source :: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2007 Oct; Vol. 24 (10), pp. 459-62. Date of Electronic Publication: 2007 Sep 01.
Publication Year :: 2007
Abstract: Purpose: To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.<br />Method: Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.<br />Results: Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.<br />Conclusion: The results suggest that hyperhomocysteinemia could affect IVF outcome.