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Characteristics and reversibility of dementia in Normal Pressure Hydrocephalus.
- Source :
-
Behavioural neurology [Behav Neurol] 2007; Vol. 18 (3), pp. 149-58. - Publication Year :
- 2007
-
Abstract
- Studies of the cognitive outcome after shunt insertion for treatment of Normal Pressure Hydrocephalus have reported widely mixed results. We prospectively studied performance of 60 patients with Normal Pressure Hydrocephalus on a comprehensive battery of neuropsychological tests before and after shunt surgery to determine which cognitive functions improve with shunt insertion. We also administered a subset of cognitive tests before and after temporary controlled drainage of cerebrospinal fluid to determine if change on this brief subset of tests after drainage could predict which patients would show cognitive improvement three to six months after shunt insertion. There was a significant improvement in learning, retention, and delayed recall of verbal memory three to six months after surgery (using paired t-tests). The majority (74%) of patients showed significant improvement (by at least one standard deviation) on at least one of the memory tests. Absence of improvement on verbal memory after temporary drainage of cerebrospinal fluid had a high negative predictive value for improvement on memory tests at 3-6 months after surgery (96%; p=0.0005). Also, the magnitude of improvement from Baseline to Post-Drainage on few specific tests of learning and recall significantly predicted the magnitude of improvement after shunt surgery on the same tests (r2=0.32-0.58; p=0.04-0.001). Results indicate that testing before and after temporary drainage may be useful in predicting which patients are less likely to improve in memory with shunting.
- Subjects :
- Aged
Cognition Disorders diagnosis
Cognition Disorders etiology
Dementia diagnosis
Female
Humans
Male
Memory Disorders diagnosis
Memory Disorders etiology
Neuropsychological Tests
Postoperative Period
Severity of Illness Index
Surveys and Questionnaires
Treatment Outcome
Ventriculoperitoneal Shunt
Dementia etiology
Hydrocephalus, Normal Pressure complications
Hydrocephalus, Normal Pressure surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0953-4180
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Behavioural neurology
- Publication Type :
- Academic Journal
- Accession number :
- 17726243
- Full Text :
- https://doi.org/10.1155/2007/456281