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A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2007 Jul; Vol. 60 (7), pp. 459-62. - Publication Year :
- 2007
-
Abstract
- A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 60
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 17721005
- Full Text :
- https://doi.org/10.1038/ja.2007.59