Back to Search
Start Over
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2007 Sep 19; Vol. 55 (19), pp. 7701-6. Date of Electronic Publication: 2007 Aug 23. - Publication Year :
- 2007
-
Abstract
- Fucoxanthin is a marine carotenoid found in edible brown seaweeds. We previously reported that dietary fucoxanthin attenuates the weight gain of white adipose tissue (WAT) of diabetic/obese KK- A(y) mice. In this study, to evaluate the antiobesity and antidiabetic effects of fucoxanthin and fish oil, we investigated the effect on the WAT weight, blood glucose, and insulin levels of KK- A(y) mice. Furthermore, the expression level of uncoupling protein 1 (UCP1) and adipokine mRNA in WAT were measured. After 4 weeks of feeding, 0.2% fucoxanthin in the diet markedly attenuated the gain of WAT weight in KK- A(y) mice with increasing UCP1 expression compared with the control mice. The WAT weight of the mice fed 0.1% fucoxanthin and 6.9% fish oil was also significantly lower than that of the mice fed fucoxanthin alone. In addition, 0.2% fucoxanthin markedly decreased the blood glucose and plasma insulin concentrations in KK- A(y) mice. The mice fed with the combination diet of 0.1% fucoxanthin and fish oil also showed improvements similar to that of 0.2% fucoxanthin. Leptin and tumor necrosis factor (TNFalpha) mRNA expression in WAT were significantly down-regulated by 0.2% fucoxanthin. These results suggest that dietary fucoxanthin decreases the blood glucose and plasma insulin concentration of KK- A(y) along with down-regulating TNFalpha mRNA. In addition, the combination of fucoxanthin and fish oil is more effective for attenuating the weight gain of WAT than feeding with fucoxanthin alone.
- Subjects :
- Adipose Tissue pathology
Animals
Diabetes Mellitus blood
Diabetes Mellitus pathology
Diabetes Mellitus therapy
Female
Mice
Mice, Obese
Obesity blood
Obesity pathology
Blood Glucose analysis
Diet
Fish Oils administration & dosage
Obesity therapy
Weight Gain drug effects
Xanthophylls administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8561
- Volume :
- 55
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17715888
- Full Text :
- https://doi.org/10.1021/jf071569n