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Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis.
- Source :
-
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2007 Aug; Vol. 85 (4), pp. 477-83. - Publication Year :
- 2007
-
Abstract
- Che-1/AATF (Che-1) was originally characterized as an interacting protein for RNA polymerase II. In addition to transcriptional regulation, the evidence suggests that Che-1 has a viral factor-like S phase promoting role in counteracting Rb repression to facilitate E2F-dependent transactivation during G1-S transition. Recently, Che-1 was found to play an important role in the DNA damage response and cell-cycle checkpoint control. Genetic studies in mice revealed that Che-1 is essential for preimplantation development and the establishment of embryonic gene expression. Importantly, several findings showed that Che-1 participates in inhibiting apoptotic process. Thus, Che-1 emerges as an important adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis.
- Subjects :
- Amino Acid Sequence
Animals
Apoptosis Regulatory Proteins genetics
Genes, cdc
Humans
Leukemia metabolism
Molecular Sequence Data
Repressor Proteins genetics
Sequence Alignment
Transcription Factors genetics
Apoptosis physiology
Apoptosis Regulatory Proteins metabolism
Cell Cycle physiology
Gene Expression Regulation
Repressor Proteins metabolism
Transcription Factors metabolism
Transcription, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0829-8211
- Volume :
- 85
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemistry and cell biology = Biochimie et biologie cellulaire
- Publication Type :
- Academic Journal
- Accession number :
- 17713582
- Full Text :
- https://doi.org/10.1139/O07-062