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Oral antibiotics attenuate bowel segment reversal-induced systemic inflammatory response and body weight loss in massively bowel-resected rats.
- Source :
-
JPEN. Journal of parenteral and enteral nutrition [JPEN J Parenter Enteral Nutr] 2007 Sep-Oct; Vol. 31 (5), pp. 397-405. - Publication Year :
- 2007
-
Abstract
- Background: Using a massively bowel-resected rat model, our previous study demonstrated that small bowel segment reversal stimulates jejunal hyperplasia but may also increase the possibility of bacterial translocation and the elevation of circulating white blood cells and serum interleukin-6 that may reduce the whole-body anabolism. The aim of this study is to investigate whether oral antibiotics might attenuate the inflammatory responses and might therefore facilitate the beneficial effects of bowel segment reversal.<br />Methods: Male Wistar rats (approximately 270 g) underwent a 70% small bowel resection with (REV group) or without (CON group) a 3-cm small bowel segment reversal, or underwent a sham operation (SHAM group). After surgeries, half of the animals in the REV group were given oral clindamycin plus amoxicillin (50 plus 50 mg/kg/d, ANT group) for 3 weeks.<br />Results: Oral antibiotics administration significantly attenuated the decreases in feeding efficiency (g of body weight/100 kcal diet) and increases in the circulation of white blood cells, serum nitric oxide, and interleukin-6 (1-way ANOVA, p < .05), which are associated with bowel segment reversal. In addition, antibiotics significantly increased serum concentrations of insulin-like growth factor-I, significantly decreased the total numbers of bacteria in the intestine, and tended to reduce the extent of jejunal hyperplasia in rats with bowel segment reversal.<br />Conclusions: Our results suggest that oral antibiotics may be used as an adjuvant to attenuate the inflammatory responses and to enhance the anabolic responses in massively bowel-resected patients with bowel segment reversal.
- Subjects :
- Adaptation, Physiological drug effects
Adaptation, Physiological physiology
Amoxicillin pharmacology
Analysis of Variance
Animals
Clindamycin pharmacology
Eating
Insulin-Like Growth Factor I metabolism
Interleukin-6 blood
Leukocyte Count
Male
Nitric Oxide blood
Random Allocation
Rats
Rats, Wistar
Short Bowel Syndrome surgery
Anti-Bacterial Agents pharmacology
Bacterial Translocation drug effects
Hyperplasia prevention & control
Intestine, Small pathology
Intestine, Small surgery
Short Bowel Syndrome complications
Weight Loss drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0148-6071
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- JPEN. Journal of parenteral and enteral nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 17712148
- Full Text :
- https://doi.org/10.1177/0148607107031005397