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The effect of some microsomal enzyme inducers on amitriptyline distribution in rats.
- Source :
-
Polish journal of pharmacology and pharmacy [Pol J Pharmacol Pharm] 1991 Jan-Feb; Vol. 43 (1), pp. 27-32. - Publication Year :
- 1991
-
Abstract
- The influence of different types of enzyme inducers: phenobarbital, Aroclor 1254 and benzo(a)pyrene, on distribution of amitriptyline and its metabolite nortriptyline in rats was investigated. The level of amitriptyline and nortriptyline in serum, brain, heart and liver was determined by gas chromatography. The maximum concentration values of amitriptyline and nortriptyline as well as areas under concentration-time curves (AUC0-6) in serum and organs were statistically compared using Student t test and AUCCOMP computer program. The results suggest that studied xenobiotics significantly influence the distribution of amitriptyline and nortriptyline in rats. The changes of these drugs concentration in target organs may be very important from the toxicological point of view.
- Subjects :
- Animals
Aroclors pharmacology
Benzo(a)pyrene pharmacology
Chlorodiphenyl (54% Chlorine)
Chromatography, Gas
Male
Microsomes, Liver drug effects
Mixed Function Oxygenases biosynthesis
Nortriptyline pharmacokinetics
Phenobarbital pharmacology
Rats
Rats, Inbred Strains
Amitriptyline pharmacokinetics
Enzyme Induction drug effects
Microsomes, Liver enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0244
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Polish journal of pharmacology and pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 1771161