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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus.
- Source :
-
Neurochemical research [Neurochem Res] 2008 Jan; Vol. 33 (1), pp. 179-84. Date of Electronic Publication: 2007 Aug 22. - Publication Year :
- 2008
-
Abstract
- Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.
Details
- Language :
- English
- ISSN :
- 0364-3190
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 17710540
- Full Text :
- https://doi.org/10.1007/s11064-007-9434-6