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Testicular carcinoma in situ in subfertile Danish men.
- Source :
-
International journal of andrology [Int J Androl] 2007 Aug; Vol. 30 (4), pp. 406-11; discussion 412. - Publication Year :
- 2007
-
Abstract
- Carcinoma in situ (CIS) testis is the precursor stage for the majority of testicular germ cell tumours (TGCT). Infertility is one of the conditions known to predispose to TGCT, but based on scarce existing data, the prevalence of CIS in this risk group was estimated at only approximately 1%. To establish more objective data, we investigated retrospectively the prevalence of CIS based on testicular biopsies performed in a well-defined group of subfertile males. We included 453 patients who had testicular biopsies performed for infertility reasons during 1995-2005 at the Copenhagen University Hospital (Rigshospitalet). Biopsies were evaluated by two experienced observers independently. CIS was detected in 10 individuals, of whom three had bilateral CIS, corresponding to a prevalence of 2.2% (95% CI 1.1-4.0%). This is greater than the estimated risk of 0.45% for the age- and birth cohort-matched general Danish population. All patients with CIS testis had severe oligozoospermia (</=2.06 million/mL). We confirmed that a thorough examination of men suffering from subfertility/infertility can identify those with an increased risk for testicular neoplasia and recommend performing bilateral biopsies, especially in the subpopulation of men with atrophic testicles, severe oligozoospermia and/or irregular ultrasonic pattern of their testicles.
- Subjects :
- Biopsy
Carcinoma in Situ pathology
Cohort Studies
Denmark epidemiology
Humans
Infertility, Male pathology
Male
Oligospermia epidemiology
Oligospermia pathology
Prevalence
Retrospective Studies
Testicular Neoplasms pathology
Testis pathology
Carcinoma in Situ epidemiology
Infertility, Male complications
Testicular Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0105-6263
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 17705813
- Full Text :
- https://doi.org/10.1111/j.1365-2605.2007.00798.x