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No association between the DRD3 Ser9Gly polymorphism and schizophrenia.
- Source :
-
Schizophrenia research [Schizophr Res] 2008 Jan; Vol. 98 (1-3), pp. 98-104. Date of Electronic Publication: 2007 Aug 14. - Publication Year :
- 2008
-
Abstract
- Objective: To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.<br />Methods: 408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).<br />Results: No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.<br />Conclusion: The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study.
- Subjects :
- Adult
Antipsychotic Agents therapeutic use
Case-Control Studies
Diagnostic and Statistical Manual of Mental Disorders
Family
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease genetics
Genotype
Glycine genetics
Haplotypes genetics
Homozygote
Humans
Male
Pedigree
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Schizophrenia diagnosis
Schizophrenia drug therapy
Serine genetics
White People genetics
Gene Frequency
Polymorphism, Genetic
Receptors, Dopamine D3 genetics
Schizophrenia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0920-9964
- Volume :
- 98
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 17698325
- Full Text :
- https://doi.org/10.1016/j.schres.2007.07.002