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Enhancement of intravesical delivery with Syn3 potentiates interferon-alpha2b gene therapy for superficial bladder cancer.
- Source :
-
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2007 Oct-Dec; Vol. 18 (5-6), pp. 389-94. Date of Electronic Publication: 2007 Aug 09. - Publication Year :
- 2007
-
Abstract
- Intravesical administration of interferon alpha-2b protein (IFN) has been successfully used in the treatment of patients with superficial bladder tumors. Local dosing of IFN minimizes well-known systemic side effects of the drug, but exposure to bladder tumors is limited by the duration of instillation and transient concentrations achieved in the urothelium. Intravesical delivery of the gene encoding interferon results in an alternative strategy for IFN-based therapy of the disease, enabling sustained exposure of IFN protein that results from production by tumor and non-tumor cells in the urothelium. Efficient gene delivery and expression of IFN has been achieved using a recombinant adenovirus gene delivery system (rAd-IFN) in conjunction with the novel small molecule excipient Syn3. Studies with rAd-IFN/Syn3 in animal models result in urine concentrations of IFN that persisted for weeks and correlated with potent anti-tumor effects. The objective of this review is to communicate the rationale and preclinical findings that support ongoing clinical investigation of intravesical rAd-IFN/Syn3 in superficial bladder cancer.
- Subjects :
- Adenoviridae genetics
Administration, Intravesical
Animals
Cholic Acids therapeutic use
Disaccharides therapeutic use
Excipients therapeutic use
Genetic Therapy
Humans
Interferon alpha-2
Interferon-alpha therapeutic use
Recombinant Proteins
Urinary Bladder Neoplasms metabolism
Urothelium metabolism
Cholic Acids administration & dosage
Disaccharides administration & dosage
Excipients administration & dosage
Interferon-alpha administration & dosage
Interferon-alpha genetics
Urinary Bladder Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1359-6101
- Volume :
- 18
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Cytokine & growth factor reviews
- Publication Type :
- Academic Journal
- Accession number :
- 17692556
- Full Text :
- https://doi.org/10.1016/j.cytogfr.2007.06.007