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Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
- Source :
-
Science (New York, N.Y.) [Science] 2007 Aug 03; Vol. 317 (5838), pp. 670-4. - Publication Year :
- 2007
-
Abstract
- The chemokines CCL21 and CXCL13 are immune factors that dictate homing and motility of lymphocytes and dendritic cells in lymphoid tissues. However, the means by which these chemokines are regulated and how they influence cell trafficking during immune responses remain unclear. We show that CCL21 and CXCL13 are transiently down-regulated within lymphoid tissues during immune responses by a mechanism controlled by the cytokine interferon-gamma. This modulation was found to alter the localization of lymphocytes and dendritic cells within responding lymphoid tissues. As a consequence, priming of T cell responses to a second distinct pathogen after chemokine modulation became impaired. We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues.
- Subjects :
- Adoptive Transfer
Animals
Arenaviridae Infections immunology
B-Lymphocytes immunology
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Cell Movement
Chemokine CCL19
Chemokine CCL21
Chemokine CXCL13
Chemokines, CC genetics
Chemokines, CXC genetics
Cytokines immunology
Cytokines metabolism
Dendritic Cells immunology
Down-Regulation
Female
Homeostasis
Interferon-gamma immunology
Interferon-gamma metabolism
Lymphocytic choriomeningitis virus
Male
Mice
Mice, Inbred Strains
Mice, Transgenic
RNA, Messenger genetics
RNA, Messenger metabolism
Chemokines, CC metabolism
Chemokines, CXC metabolism
Listeriosis immunology
Lymph Nodes immunology
Spleen immunology
Virus Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 317
- Issue :
- 5838
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 17673664
- Full Text :
- https://doi.org/10.1126/science.1144830