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Lymphopenia is associated with neuropsychiatric manifestations and disease activity in paediatric systemic lupus erythematosus patients.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2007 Sep; Vol. 46 (9), pp. 1492-4. Date of Electronic Publication: 2007 Aug 01. - Publication Year :
- 2007
-
Abstract
- Objectives: To investigate if lymphopenia is associated with clinical manifestations, disease activity and prognosis in systemic lupus erythematosus (SLE).<br />Methods: The charts of 186 paediatric patients with SLE diagnosed between 1985 and 2006 in a medical centre were retrospectively reviewed. Lymphocyte counts were recorded at the time of SLE diagnosis and SLE flares. Global disease activity was quantified by the SLE Disease Activity Index (SLEDAI). Cumulative organ damage was assessed by the ACR/Systemic Lupus International Collaborating Clinics (SLICC) damage index.<br />Results: Lymphopenia (<1500/mm(3)) and marked lymphopenia (<500/mm(3)) was observed in 62.8 and 12.2% at the time of SLE diagnosis. At the time of SLE diagnosis, lymphopenia was significantly associated with oral ulcers, leucopenia, anti-dsDNA antibodies and C4 decrease. At the time of flares, lymphopenia was significantly associated with anti-dsDNA antibodies, methylprednisolone pulse therapy, disease activity and organ damage. Using multivariate logistic regression, marked lymphopenia was independently associated with neuropsychiatric manifestations [odds ratio (OR) 7.41, 95% confidence interval (CI) 1.99-27.0], and protective from LN (OR 0.13, 95% CI 0.03-0.53).<br />Conclusions: Lymphopenia at SLE flares is associated with disease activity and organ damage. Marked lymphopenia is independently associated with neuropsychiatric manifestations.
- Subjects :
- Adolescent
Antibodies, Antinuclear blood
Child
Child, Preschool
DNA immunology
Female
Humans
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic complications
Lupus Erythematosus, Systemic drug therapy
Lupus Vasculitis, Central Nervous System blood
Male
Retrospective Studies
Risk Factors
Severity of Illness Index
Lupus Vasculitis, Central Nervous System complications
Lymphopenia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0324
- Volume :
- 46
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 17673480
- Full Text :
- https://doi.org/10.1093/rheumatology/kem182